OUR PORTFOLIO

We work together with leading companies and research institutes and strive to jointly publish most of our work in scientific journals to contribute to the advancement of the collective scientific knowlegde.

OUR PARTNERS & CLIENTS

OUR KEY PUBLICATIONS

A Molecular Landscape of Stress Urinary Incontinence in Women Suggests an Important Role of Beta-Catenin Signaling in Disease Etiology

01/04/2023

Authors: WM Post, J Widomska, E Oosterwijk, W De Witte, MJH Coenen, DAW Janssen, F Martens, R Cartwright, VA Minassian, KL Penney, LF Thomas, AH Skogholt, SN Stafne, K Hveem, KB Kluivers, G Poelmans

Published in:
JU Open Plus

Stress Urinary Incontinence

Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology

23/03/2023

Authors: KB Kluivers, SL Lince, AM Ruiz-Zapata, WM Post, R Cartwright, MH Kerkhof, J Widomska, W De Witte, J Pecanka, LA Kiemeney, SH Vermeulen, JJ Goeman, K Allen-Brady, E Oosterwijk, G Poelmans

Published in:
Int J Mol Sci.

Pelvic Organ Prolapse

Molecular Landscape of Tourette's Disorder

11/01/2023

Authors: J Widomska, W De Witte, JK Buitelaar, JC Glennon, G Poelmans

Published in:
Int J Mol Sci.

Tourette’s disorder

Whole Exome Sequencing in Multi-Incident Families Identifies Novel Candidate Genes for Multiple Sclerosis

28/09/2022

Authors: J Horjus, T van Mourik-Banda, MAP Heerings, M Hakobjan, W De Witte, DJ Heersema, AJ Jansen, EMM Strijbis, BA de Jong, AEJ Slettenaar, EMPE Zeinstra, ELJ Hoogervorst, B Franke, W Kruijer, PJ Jongen, LJ Visser, G Poelmans

Published in:
Int J Mol Sci.

Multiple Sclerosis

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

14/02/2022

Authors: G Fanelli, B Franke, W De Witte, IH Ruisch, J Haavik, V van Gils, WJ Jansen, SJB Vos, L Lind, JK Buitelaar, T Banaschewski, S Dalsgaard, A Serretti, N Roth Mota, G Poelmans, J Bralten

Published in:
Transl Psychiatry

Insulin

Genetic overlap between Alzheimer's disease and blood lipid levels

01/12/2021

Authors: RJ van der Linden, LM Reus, W De Witte, BM Tijms, M Olde Rikkert, PJ Visser, G Poelmans

Published in:
Neurobiol Aging

Alzheimer’s disease

Shared Genetic Etiology between Alzheimer's Disease and Blood Levels of Specific Cytokines and Growth Factors

05/06/2021

Authors: RJ van der Linden, W De Witte, G Poelmans

Published in:
Genes (Basel)

Alzheimer’s disease

Genetic underpinnings of sociability in the general population

01/08/2021

Authors: J Bralten*, NR Mota*, CJHM Klemann*, W De Witte, E Laing, DA Collier, H de Kluiver, SEEC Bauduin, C Arango, JL Ayuso-Mateos, C Fabbri, MJ Kas, N van der Wee, BWJH Penninx, A Serretti, B Franke, G Poelmans

Published in:
Neuropsychopharmacology

Sociability

Shared genetic etiology between Parkinson's disease and blood levels of specific lipids

05/03/2021

Authors: H Xicoy, CJHM Klemann, W De Witte, MB Martens, GJM Martens, G Poelmans

Published in:
NPJ Parkinson’s disease

Parkinson’s disease

Long genes are more frequently affected by somatic mutations and show reduced expression in Alzheimer's disease: Implications for disease etiology

01/03/2021

Authors: S Soheili-Nezhad, RJ van der Linden, M Olde Rikkert, E Sprooten, G Poelmans

Published in:
Alzheimers Dement.

Alzheimer’s disease

Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

27/04/2020

Authors: J Bralten, J Widomska, W De Witte, D Yu, CA Mathews, JM Scharf, J Buitelaar, J Crosbie, R Schachar, P Arnold, M Lemire, CL Burton, B Franke, G Poelmans

Published in:
Transl Psychiatry

OCD; Insulin

Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures

01/06/2020

Authors: NR Mota, G Poelmans, M Klein, B Torrico, N Fernàndez-Castillo, B Cormand, A Reif, B Franke, AA Vásquez

Published in:
Neuropsychopharmacology

ADHD; Obesity

Converging evidence points towards a role of insulin signaling in regulating compulsive behavior

12/09/2019

Authors: IIGM van de Vondervoort, H Amiri, MMK Bruchhage, CA Oomen, N Rustogi, JD Cooper, JJA van Asten, A Heerschap, S Bahn, SCR Williams, JK Buitelaar, G Poelmans, JC Glennon

Published in:
Transl Psychiatry

OCD; Insulin

Riluzole Attenuates L-DOPA-Induced Abnormal Involuntary Movements Through Decreasing CREB1 Activity: Insights from a Rat Model

01/07/2019

Authors: L Pagliaroli, J Widomska, E Nespoli, T Hildebrandt, C Barta, J Glennon, B Hengerer, G Poelmans

Published in:
Mol Neurobiol

Dyskinesia; Riluzole

Physical Exercise Modulates L-DOPA-Regulated Molecular Pathways in the MPTP Mouse Model of Parkinson's Disease

01/07/2018

Authors: CJHM Klemann, H Xicoy, G Poelmans, BR Bloem, GJM Martens, JE Visser

Published in:
Mol Neurobiol

Parkinson’s disease

Autism spectrum disorders and autistic traits share genetics and biology

01/05/2018

Authors: J Bralten, KJ van Hulzen, MB Martens, TE Galesloot, AA Vasquez, LA Kiemeney, JK Buitelaar, JW Muntjewerff, B Franke, G Poelmans

Published in:
Mol Psychiatry

ASD; autistic traits

Integrated molecular landscape of amyotrophic lateral sclerosis provides insights into disease etiology

28/03/2018

Authors: CJHM Klemann, JE Visser, L Van Den Bosch, GJM Martens, G Poelmans

Published in:
Brain pathology

Amyotrophic lateral sclerosis

Integrated molecular landscape of Parkinson's disease

10/04/2017

Authors: CJHM Klemann, GJM Martens, M Sharma, MB Martens, O Isacson, T Gasser, JE Visser, G Poelmans

Published in:
NPJ Parkinson’s disease

Parkinson’s disease

An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder

01/06/2016

Authors: I van de Vondervoort, G Poelmans, A Aschrafi, DL Pauls, JK Buitelaar, JC Glennon, B Franke

Published in:
J Psychiatry Neurosci

OCD

Validity of the MPTP-Treated Mouse as a Model for Parkinson's Disease

01/04/2016

Authors: CJHM Klemann, GJM Martens, G Poelmans, JE Visser

Published in:
Mol Neurobiol

Parkinson’s disease

MicroRNA-137 regulates a glucocorticoid receptor-dependent signalling network: implications for the etiology of schizophrenia

10/04/2017

Authors: A Vallès, GJM Martens, P De Weerd, G Poelmans, A Aschrafi

Published in:
J Psychiatry Neurosci

Schizophrenia

AKAPs integrate genetic findings for autism spectrum disorders

11/06/2013

Authors: G Poelmans, B Franke, DL Pauls, JC Glennon, JK Buitelaar

Published in:
Transl Psychiatry

ASD

Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function

01/03/2012

Authors: EA Fliers, AA Vasquez, G Poelmans, N Rommelse, M Altink, C Buschgens, P Asherson, T Banaschewski, R Ebstein, M Gill, A Miranda, F Mulas, RD Oades, H Roeyers, A Rothenberger, J Sergeant, E Sonuga-Barke, H-C Steinhausen, SV Faraone, JK Buitelaar, B Franke

Published in:
World J Biol Psychiatry

ADHD

Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder

01/04/2011

Authors: G Poelmans, DL Pauls, JK Buitelaar, B Franke

Published in:
Am J Psychiatry

ADHD

A theoretical molecular network for dyslexia: integrating available genetic findings

01/04/2011

Authors: G Poelmans, JK Buitelaar, DL Pauls, B Franke

Published in:
Mol Psychiatry

Dyslexia